When I try to open a power point attachment on an e-mail I get a message that my security setting will not allow it. Which settings do I need to change. Some of these are work related and I need to open them.

What email program are you using?

outlook express

Since Vista did not include Outlook Express, I'll have to pass on this one.
Hopefully, someone else will jump in to give you specifics on how to enable the PP extention within Outlook Express. Good Luck...

In Outlook Express - Click Tools > Options > On the Security Tab - untick the box that says "Do not allow attachments to be saved or opened that could potentially be a virus" > Click Apply > Click OK.

Thank You