What type of mouse is it? Rollerball or optical?
This is basic, but it's the first thing to do before blaming the computer or software for it...
If roller, first thing to do is remove the ball and clean it and the wheels inside the mouse that the ball contacts.
If optical, make sure you're using it on a clean, smooth surface, preferably all one color. I've seen text and even woodgrain confuse the optic, causing similar goofiness.
For both types, make sure the cable itself isn't damaged, espcially nearest to the connector, where it tends to get sharply angled at times. Same goes for where the wire enters the mouse itself. The more use it has seen, the more likely the wire has been tortured once too many times, and is frayed inside, causing intermittent contact.
If you are NOT absolutely certain that the mouse itself is fine, replace it. New ones are dirt cheap, and $10 there beats the heck out of hours of software tweaking and settings adjustments.
If the new mouse behaves the same, it's a mere $10 lesson...and you can even return it for that $10 if you don't want it.
I've learned to treat the PC that same as my car. Replace the cheapest/easiest possible source of the problem first, and work your way toward the expensive and time-consuming bits.
As for a software culprit...it could be any number of odd things. You may have software running in the background you don't even know about that is eating up resources and causing erratic mouse behavior..anything from your own Anti-virus and/or system maintenance programs to an actual spyware or virus issue. If networked, the problem can be in transfers between the systems again eating up resources.
I recommend swapping the mouse with another (borrowed, bought... whatever- as long as it's a known good one), and if that doesn't correct it, THEN report back here and certainly someone else will be able to help troubleshoot it.
Good luck.
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 JWRosa
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