first what mail software do you use and what do you use it for i.e. sendening and reciveing emails or just as relay when i know all this i might be able to help you.
on the subject of anti-spam software i surgest you use spamassassin this is a free software to download and use you can get it from
SpamAssassin: Welcome to SpamAssassin and to help you install it on a windows system i use this website
How To Use SpamAssassin on Win32 it's very good but you will need quit a powerfull server. (the hosting company i work for uses this so i know it's very good when properly configerd, if you need help i can help you out on that one as i was the one how installed it at work) it can be installed over remote desktop if the server is in a data center.
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Look what my computer did to me:

shouldn't it be the other way around..
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Here to help others with computer problems and learn new things at the same time. No one knows everything, if they did, life would be pointless.
not bad for a 512KB conection which is the fastest i can get!!!!!