My friend thinks he's been hacked. He says he is very careful (suuuure

) but he's getting quite a few popups, can't open up programs and a ton of his stuff has been deleted and he can't get it back. My question is, is there a way to recover this stuff? He's already tried system restore. Also, how can he fix the problem? He said he's done scans with basically all known programs and it didn't fix it. He also can't boot into safe mode. When he holds F8, it does nothing. When he tries to select safe mode from the startup options, it will not let him. Also, in msconfig, the BOOT.INI tab has been completely removed. Suggestions?