OK, Wife's laptop now runs the Scrabble game without needing to drag that darn CD disc around.

For others, use the following:
Alcohol 52% (virtualCD app) CD and DVD Burning Software - Alcohol 120% - Alcohol 52% and Alcohol 52% Free
and
Y.A.S.U. (IDE drive mask) Yasu

Alcohol 52% creates the virtual CD drive that you can mount the Scrabble game on, so you won't need the disc, but the SecuROM copy protection that Encore/Hasbro/Gamehouse uses looks to see if a SCSI drive is present (which the virtual CD drive is) and will block if IDE drives are also present. So Y.A.S.U. will hide or mask the IDE drive(s) and force SecuROM to use the virtual drive.

Cheers, and good Scrabbling!!!
Jim