At first look as I am not a hijackthis expert I know you do not have an ativrus program or firewall?
O dop know you can rerun hijackthis and have it clean these entries. But please before you do this save hijack this inot your documents so it can make a backup
R1 - HKCU\Software\Microsoft\Internet Explorer,SearchURL =
http://letgohome.com/sp.htm?id=34332
1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page =
http://websearch.drsnsrch.com/sidesearch.cgi?id=
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Bar =
http://websearch.drsnsrch.com/sidesearch.cgi?id=
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,SearchAssistant = C:\WINDOWS\_s.html
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,SearchAssistant = C:\WINDOWS\_s.html
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page =
http://websearch.drsnsrch.com/sidesearch.cgi?id=
R1 - HKCU\Software\Microsoft\Internet Explorer\Search,SearchAssistant =
http://letgohome.com/sp.htm?id=34332
R1 - HKCU\Software\Microsoft\Internet Explorer\Search,(Default) = C:\WINDOWS\_s.html
R3 - URLSearchHook: (no name) - _{CFBFAE00-17A6-11D0-99CB-00C04FD64497} - (no file)
R3 - URLSearchHook: (no name) - _{5D60FF48-95BE-4956-B4C6-6BB168A70310} - (no file)
R3 - URLSearchHook: (no name) - _{855F3B16-6D32-4fe6-8A56-BBB695989046} - (no file)
O2 - BHO: (no name) - {467FAEB2-5F5B-4c81-BAE0-2A4752CA7F4E} - (no file)
Edit Upon looking this entry ma be why your cursor will not show up
O4 - HKLM\..\Run: [DM_Server] C:\PROGRA~1\COMETS~1\DM\BIN\DMSERVER.EXE /onreboot
Do you have this software installed?
Aslo you may want to download lspfix before joe gets to you.
http://www.cexx.org/lspfix.htm
You wont have to reofrmat though!!
And you have alot of startup programs as well. Maybe why so sluggish.. Wait untill Joe5 looks at the whole list since I am not really experienced at this but I know some of it;.