When you installed the new
cpu cooler - did you apply new thermal compound? And also did you clean the old compound off the
cpu properly before applying new compound.
Otherwise unplug all hardware, etc from your motherboard and replug in just the basics required for it boot. E.g. Harddrive, GC,
Ram. Check the connections to the hard drive and make sure it is connected to the right slot on the motherboard. Make sure that the back of the motherboard is not shorting out on the case.