My first (and only) guess would be your hard drive is failing. I would back up all your important data ASAP while you can still get into your OS.
The only part in the computer that has moving parts that could affect your computer from acting properly is the hard drive. All the other core components (motherboard, video card, memory, etc.) don't have any moving parts except for fans. But if your fans were the problem, your computer would boot fine in either position but might overheat after a while.
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