I've been using NOD32 for a few months after switching from McAfee. But I thought McAfee was a little more user-friendly and I enjoyed using it. Now i'm considering looking for another alternative, maybe something you guys would recommend? (price doesn't matter, just taking opinions )

My favorites are Avast! Anti-Virus and Grisoft AVG Free. They are both free and are not resource hogs like you typically see in commercial AV software.

I recently gave Norton the boot and installed an Avast/ZoneAlarm combination and so far my computer is running better and they are doing just as good of a job.

Second that-- but I use AVG/ZoneAlarm.
AVG does it's job so well... and quietly that I once discovered an item in the Quarantine that I did not even notice for 2 months.
It updates/runs itself late at night... I hardly know it's running.

Zone Alarm take a little getting used to-- it "learns" your system by alerting a lot at first--because it also detects programs accessing the net from your PC. So if something like trojan slipped through-- it would catch it trying to "call home". It also watches installers--
When it alerts-- there is a 'more info' link --so if you are not sure you want to allow the app-- you can check it first-- before any potential damage.

Yeah, my entire family has been mad at me because now that Norton is gone ZA has to figure out what to do with everything and they're getting sick of the alerts.

One downside to ZA is that if there is more than one account logged on - it will display alerts for all accounts, not just the one trying to run the program.

I'd also recommend ClamWin Anti-Virus

I was running it for a while before i moved to Vista.
And i just use the Windows Firewall and don't do anything silly

Yeah but you don't have a brother who visits Heaven knows what on the internet . I can't take any chances :P.